Determination of the nucleoside triphosphate contents of eggs and oocytes of Xenopus laevis. NLM Our servers have detected that you are accessing this site from a country that is a member of the European Union. Using a sensitive enzymic assay, we have measured the concentrations (pools) of these compounds in human bone marrow cells and in lymphocytes.

 |  Eur J Clin Pharmacol. This site needs JavaScript to work properly. Elevated adenosine deaminase activity and hereditary hemolytic anemia. J Clin Invest. 2016 Apr 12;113(15):4027-32. doi: 10.1073/pnas.1524212113. NIH HHS Get the latest research from NIH: https://www.nih.gov/coronavirus. 1985;28(3):287-90. doi: 10.1007/BF00543325. Deoxycoformycin in the treatment of mature T-cell leukaemias. Get the latest public health information from CDC: https://www.coronavirus.gov.  |  Ecto-adenosine triphosphatase deficiency in cultured human T and null leukemic lymphocytes. Epub 2016 Mar 28. Clipboard, Search History, and several other advanced features are temporarily unavailable. 1981 Aug;68(2):544-52. doi: 10.1172/jci110286. DNA replication and repair require each of the four canonical deoxyribonucleoside triphosphates (dNTPs). Dibutyryl cyclic 3', 5' adenosine monophosphate and theophylline had no consistent effect on the deoxyribonucleoside triphosphate concentrations. INTRODUCTION. [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity. The toxicity of the deoxyribonucleosides, 2'-deoxyadenosine, 2'-deoxyguanosine, and thymidine, for human T lymphoblasts is mediated by the accumulation of the corresponding deoxyribonucleoside triphosphate (dATP, dGTP, or dTTP, respectively).  |  USA.gov. A deoxynucleoside triphosphate is a nucleotide containing 3 phosphate groups attached to the 5' carbon of the deoxyribose sugar of the nucleoside.There are four different deoxynucleoside triphosphates; deoxyadenosine-5' triphosphate (dATP), deoxyguanosine-5' triphosphate (dGTP), deoxythymidine-5' triphosphate (dTTP), deoxycytidine-5' triphosphate (dCTP) It has a role as an Escherichia coli metabolite and a mouse metabolite. A biochemical basis for thymidine sensitivity. The deoxyribonucleoside triphosphate concentrations were increased approximately threefold in the nucleated marrow cells from patients with leukaemia and myeloproliferative diseases. Oncogenic transformation of C3H/10T1/2 Cl 8 mouse embryo fibroblasts by inhibitors of nucleotide metabolism. 2015 Sep;10(3):396-401. doi: 10.1007/s11481-015-9624-y. PHA-stimulation of lymphocytes caused a marked increase of the deoxyribonucleoside triphosphate concentrations, particularly of dTTP, between 24 and 48 h of culture. 6-Mercaptopurine caused a fall in dATP and dGTP, the fall in dATP being marked after 4 h incubation. Copyright © 2014 Health Grades Inc. All rights reserved. We have found that non-T, non-B acute lymphoblastic leukemia cells with low ecto-5'-nucleotidase and high adenosine deaminase activities increase their dATP pools by greater than tenfold when exposed to deoxyadenosine and an inhibitor of adenosine deaminase in culture.

1987 Mar;79(3):1001-5. doi: 10.1172/JCI112866. Deoxyribonucleoside triphosphate: Related Topics. It is concluded that measurement of the deoxyribonucleoside triphosphates in human cells provides a new method of studying DNA synthesis in human disease states and of analysing the action of antimetabolite drugs on normal and diseased cells. This site needs JavaScript to work properly. DATP is a purine 2'-deoxyribonucleoside 5'-triphosphate having adenine as the nucleobase. These medical condition or symptom topics may be relevant to medical information for Deoxyribonucleoside triphosphate: Information provided on this site is for informational purposes only; it is not intended as a substitute for advice from your own medical team.

Johnson CH, Patti GJ, Courade JP, Shriver LP, Hoang LT, Manchester M, Siuzdak G. J Neuroimmune Pharmacol. 1991 Nov;64(5):903-6. doi: 10.1038/bjc.1991.423. Deoxynucleotide triphosphate synonyms, Deoxynucleotide triphosphate pronunciation, Deoxynucleotide triphosphate translation, English dictionary definition of Deoxynucleotide triphosphate. Deoxynucleotide-interconverting enzymes and the quantification of deoxynucleoside triphosphates in mammalian cells. Deoxyadenosine triphosphate as a mediator of deoxyguanosine toxicity in cultured T lymphoblasts. 1972 Apr;127(3):597-605. doi: 10.1042/bj1270597. PHA-stimulation of lymphocytes caused a marked increase of the deoxyribonucleoside triphosphate concentrations, particularly of dTTP, between 24 and 48 h of culture.

Deoxyribonucleoside triphosphate metabolic process Antibodies Antibodies for proteins involved in deoxyribonucleoside triphosphate metabolic process pathways; according to their Panther/Gene Ontology Classification. Deoxyribonucleoside triphosphate: glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety. Evidence for abnormal translational control of protein synthesis.

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