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Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). internal Editor information: contains the name of each editor and his/her ORCID identifier. http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ Amendment of PDF/A standard For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. Arbortext Advanced Print Publisher 9.1.440/W Unicode Immunotherapy uuid:3e1f33d0-d73a-42d5-b48c-381bfcd0a476 http://ns.adobe.com/xap/1.0/sType/Font# Part Gives the name of an editor. A structure containing the characteristics of a font used in a document.
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Check for active clinical trials using this agent.
2018-06-18T13:18:09+02:00 It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates a greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes. http://springernature.com/ns/xmpExtensions/2.0/ PD-1
A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T cells and, upon activation by adenosine, inhibits their proliferation and activation. A structure containing the characteristics of a font used in a document Date when document was last modified Text
Journal for ImmunoTherapy of Cancer
Conformance level of PDF/A standard PlateNames part Text author InstanceID orcid
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internal Trapped Integer conformance Bag AuthorInformation internal Targeting adenosine for cancer immunotherapy To this
converted endobj http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ A name object indicating whether the document has been modified to include trapping information Specifies the types of editor information: name and ORCID of an editor. Specifies the types of series editor information: name and ORCID of a series editor.
GTS_PDFXVersion Text seriesEditorInfo internal Seq Text Gives the name of a series editor.
URI S8575: A2AR antagonist 1. Robert D. Leone XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). application/pdf CD73 Series editor information: contains the name of each series editor and his/her ORCID identifier. 1 A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively. xmpMM Company name internal stPart %����
EditorInformation Fonts Bag SeriesEditorInformation pdfaid It is a minimal reference; missing components can be assumed to be unchanged. Gives the ORCID of an editor. Text name converted to PDF/A-2b XMP Paged-Text AuthorInformation internal internal Text Gives the ORCID of a series editor. OriginalDocumentID orcid Conformance level of PDF/X standard uuid:7582ba65-eb8a-4e66-ae67-2caf582aa86c external Adobe PDF Schema DerivedFrom PDF/A ID Schema http://ns.adobe.com/xap/1.0/t/pg/ Adenosine,A2a receptor,Checkpoint blockade,PD-1,Immunotherapy,CD39,CD73,CTLA-4
Identifies a portion of a document. Authors show that engagement of A2A adenosine receptor (A2AR) acts as a checkpoint that limits the maturation of natural killer (NK) cells. Checkpoint blockade orcid GTS_PDFXConformance Keywords: Adenosine, A2a receptor, Checkpoint blockade, PD-1, Immunotherapy, CD39, CD73, CTLA-4 Background The ability to regulate the strength and duration of an im-mune response is a critical aspect of immunity. URI hypoxia-CD39-CD73-A2aR pathway have great promise for further improving clinical outcomes in cancer patients. Adenosine A2a receptor default
http://ns.adobe.com/xap/1.0/sType/Part# uuid:003ac616-8ac2-4277-b0c5-094d866fd828 <, Journal for ImmunoTherapy of Cancer, 2018, doi:10.1186/s40425-018-0360-8, Targeting adenosine for cancer immunotherapy. ResourceRef Gives the ORCID of an author. <>stream Both global and NK-cell-specific conditional deletion of A2AR enhanced proportions of terminally mature NK cells at homeostasis, following reconstitution, and in the tumor microenvironment. Font 2 0 obj Text Abundant extracellular adenosine can then bind to the A2A receptor resulting in a G s-protein coupled response, resulting in the accumulation of intracellular cAMP, which functions primarily through protein kinase A to upregulate inhibitory cytokines such as transforming growth factor-beta (TGF-β) and inhibitory receptors (i.e., PD-1). The common identifier for all versions and renditions of a document. external An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. This can be a position at which the document has been changed since the most recent event history (stEvt:changed).
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