/Kids [4 0 R 5 0 R 6 0 R 7 0 R 8 0 R 9 0 R 10 0 R 11 0 R 12 0 R] /Type /Page << >> NF-κB activity is initiated by…, CREB-induced IL-10 production is regulated…, CREB-induced IL-10 production is regulated by IFN-γ. TLR signaling results in the activation…, CREB promotes TGFβ-mediated generation and…, CREB promotes TGFβ-mediated generation and maintenance of FoxP3 Tregs.

/CSML#3APProt << /CSML#3APProt << endobj

/Rotate 0 1f81: SOLUTION STRUCTURE OF THE TAZ2 DOMAIN OF THE TRANSCRIPTIONAL ADAPTOR PROTEIN CBP, 1jjs: NMR Structure of IBiD, A Domain of CBP/p300, 1jsp: NMR Structure of CBP Bromodomain in complex with p53 peptide, 1kbh: Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR, 1kdx: KIX DOMAIN OF MOUSE CBP (CREB BINDING PROTEIN) IN COMPLEX WITH PHOSPHORYLATED KINASE INDUCIBLE DOMAIN (PKID) OF RAT CREB (CYCLIC AMP RESPONSE ELEMENT BINDING PROTEIN), NMR 17 STRUCTURES, 1l3e: NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex, 1l8c: STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR HYPOXIC RESPONSE, 1liq: Non-native Solution Structure of a fragment of the CH1 domain of CBP, 1p4q: Solution structure of the CITED2 transactivation domain in complex with the p300 CH1 domain, 1r8u: NMR structure of CBP TAZ1/CITED2 complex, 1sb0: Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb, 2agh: Structural basis for cooperative transcription factor binding to the CBP coactivator, 2c52: STRUCTURAL DIVERSITY IN CBP P160 COMPLEXES, 2d82: Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association, The prediction for 9aaTADs (for both acidic and hydrophilic transactivation domains) is available online from ExPASy, GO:0001105 transcription coactivator activity, RNA polymerase II transcription factor binding, GO:0001158 core promoter proximal region sequence-specific DNA binding, GO:0001104 transcription coregulator activity, RNA polymerase II activating transcription factor binding, GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific, transferase activity, transferring acyl groups, GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity, GO:0001106 transcription corepressor activity, regulation of transcription, DNA-templated, stimulatory C-type lectin receptor signaling pathway, negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription, DNA-templated, regulation of smoothened signaling pathway, regulation of transcription from RNA polymerase II promoter in response to hypoxia, transcription initiation from RNA polymerase II promoter, positive regulation of type I interferon production, positive regulation of transcription from RNA polymerase II promoter, regulation of myeloid cell differentiation, positive regulation of transcription of Notch receptor target, positive regulation of transforming growth factor beta receptor signaling pathway, positive regulation of Notch signaling pathway, GRCh38: Ensembl release 89: ENSG00000005339, GRCm38: Ensembl release 89: ENSMUSG00000022521, "Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53", "9aaTAD is a common transactivation domain recruits multiple general coactivators TAF9, MED15, CBP/p300 and GCN5", "9aaTADs mimic DNA to interact with a pseudo-DNA Binding Domain KIX of Med15 (Molecular Chameleons)", http://www.es.embnet.org/Services/EMBnetAT/htdoc/9aatad/, "Entrez Gene: CREBBP (CREB-binding protein)", "CBP-mediated post-translational N-glycosylation of BRCA2", "Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2", "Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy", "CBP alleviates the intramolecular inhibition of ATF-2 function", "The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus", "CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1", "CREB-binding protein in androgen receptor-mediated signaling", "The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein", "CBP/p300 interact with and function as transcriptional coactivators of BRCA1", "The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter", "BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit", "Factors associated with the mammalian RNA polymerase II holoenzyme", "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation", "CREB-binding [corrected] protein interacts with the homeodomain protein Cdx2 and enhances transcriptional activity", "Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress", "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein", "Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators", "p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation", "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB", "MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein", "Ca2+-dependent block of CREB-CBP transcription by repressor DREAM", "Casein kinase II interacts with the bZIP domains of several transcription factors", "Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP", "A human RNA polymerase II complex containing factors that modify chromatin structure", "Inhibition of p300/CBP by early B-cell factor", "Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles", "Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1", "DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells", "Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3", "Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300", "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1", "Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins", "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein", "CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression", "Human ING1 proteins differentially regulate histone acetylation", "Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases", "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2", "Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction", "Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex", "CREB-binding protein/p300 co-activation of crystallin gene expression", "Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP).

13 0 obj doi: 10.7717/peerj.10125.

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First isolated as a nuclear protein [Ref] that binds to cAMP-response element-binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. /#0Aq#0A 76 0 R 2020 Jun 2;9(1):1771143. doi: 10.1080/2162402X.2020.1771143.

eCollection 2020. COVID-19 is an emerging, rapidly evolving situation. In many cell types, these factors function as effector molecules that bring about cellular changes in response to discrete sets of instructions. /Resources 47 0 R

Dysregulation of CREB Function and Disease in the Nervous System CREB and Addiction CREB-binding protein has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain. Mice with a Crem(-/-) background and lacking Creb in the central nervous system during development show extensive apoptosis of postmitotic neurons. Post-Translational Modifications in Health and Disease. /Rotate 0

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https://doi.org/10.1016/S0896-6273(02)00828-0. First isolated as a nuclear protein [Ref] that binds to cAMP-response element-binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. /BM /Normal

In T and B cells, CREB activation promotes proliferation and survival and differentially regulates Th1, Th2, and Th17 responses.

Use the link below to share a full-text version of this article with your friends and colleagues. This site needs JavaScript to work properly. Molecular function Cellular component ... CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. eCollection 2020. In liver, phosphorylation is induced by fasting or … >> Immunomodulatory Effects of Diterpenes and Their Derivatives Through NLRP3 Inflammasome Pathway: A Review. Control of cellular survival and proliferation is dependent on extracellular signals and is a prerequisite for ordered tissue development and maintenance.  |  <<

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endobj Get the latest research from NIH: https://www.nih.gov/coronavirus. /Contents [76 0 R 78 0 R 77 0 R 76 0 R 58 0 R 77 0 R] /MediaBox [0 0 612 792] /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] MSK1 promotes cell proliferation and metastasis in uveal melanoma by phosphorylating CREB. /#0Aq#0A 84 0 R

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>> << << HHS CREB has a Role in Neurogenesis and Neuronal Differentiation.

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