Am J Physiol Heart Circ Physiol 282:H49–H57, Talukder MA, Morrison RR, Ledent C, Mustafa SJ (2003) Endogenous adenosine increases coronary flow by activation of both A, Tang L, Parker M, Fei Q, Loutzenhiser R (1999) Afferent arteriolar adenosine A, Tawfik HE, Schnermann J, Oldenburg PJ, Mustafa SJ (2005) Role of A, Tawfik HE, Teng B, Morrison RR, Schnermann J, Mustafa SJ (2006) Role of A, Teng B, Qin W, Ansari HR, Mustafa SJ (2005) Involvement of p38-mitogen-activated protein kinase in adenosine receptor-mediated relaxation of coronary artery. Adenosine is known to regulate myocardial and coronary circulatory functions. Currently, there are four known adenosine receptor (AR) subtypes, namely A1, A2A, A2B, and A3. The increasing popularity of gene-modified models with targeted deletion or overexpression of a single AR subtype has helped to elucidate the roles of each receptor subtype. Adenosine is an autacoid that plays a critical role in regulating cardiac function, including heart rate, contractility, and coronary flow. Hypertension 33:1441–1446, Lindsay BD (2007) Focal and macroreentrant atrial tachycardia: from bench to bedside and back to the bench again.

Klin Wochenschr 44:1307–1310, Germack R, Dickenson JM (2004) Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes.

J Physiol 570:85–96, Reichelt ME, Willems L, Molina JG, Sun CX, Noble JC, Ashton KJ, Schnermann J, Blackburn MR, Headrick JP (2005) Genetic deletion of the A, Rekik M, Mustafa JS (2003) Modulation of A, Resh W, Feuer J, Wesley RC, Jr. (1992) Intravenous adenosine: a noninvasive diagnostic test for sick sinus syndrome. Heart Block Adenosine injection exerts its effect by decreasing conduction through the A-V node and may produce a short lasting first-, second- or third-degree heart block.

Adenosine has far-reaching effects as an extracellular signaling molecule inducing vasodilation in most vascular beds, regulating activity in the sympathetic nervous system, having antithrombotic properties, and reducing blood pressure and heart rate.

Cardiovasc Res 27:54–61, Pelleg A, Kutalek SP (1997) Adenosine in the mammalian heart: nothing to get excited about.

Cardiovasc Res 62:: 500–508, Feoktistov I, Biaggioni I (1997) Adenosine A, Flammang D, Pelleg A, Benditt DG (2005) The adenosine triphospate (ATP) test for evaluation of syncope of unknown origin. J Mol Cell Cardiol 44:905–914, Tune JD, Gorman MW, Feigl EO (2004) Matching coronary blood flow to myocardial oxygen consumption.

Am J Physiol 266:H2018–H2025, Abebe W, Hussain T, Olanrewaju H, Mustafa SJ (1995) Role of nitric oxide in adenosine receptor-mediated relaxation of porcine coronary artery. Heart rate (HR), body temperature (Temp), locomotor activity (LA), and oxygen consumption (O(2)C) were studied in awake mice lacking one or both of the adenosine A(1) or A(2A) receptors (A(1)R or A(2A)R, respectively) using telemetry and respirometry, before and after caffeine administration. Selective A(2B) antagonism had little or no effect.

Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. J Am Coll Cardiol 49:1324–1333, Markowitz SM, Stein KM, Mittal S, Slotwiner DJ, Lerman BB (1999) Differential effects of adenosine on focal and macroreentrant atrial tachycardia. receptors that are responsible for inhibition of adenylyl cyclase activ-ity and A2 receptors that are responsible for stim-ulation of this enzyme activity. Trends Pharmacol Sci 18:236–238, Peterman C, Sanoski CA (2005) Tecadenoson: a novel, selective A, Pelleg A, Mitamura H, Mitsuoka T, Michelson EL, Dreifus LS (1986) Effects of adenosine and adenosine 5, Pelleg A, Hurt C, Miyagawa A, Michelson EL, Dreifus LS (1990a) Differential sensitivity of cardiac pacemakers to exogenous adenosine in vivo. Circulation 106:2793–2799, Iwai S, Cantillon DJ, Kim RJ, Markowitz SM, Mittal S, Stein KM, Shah BK, Yarlagadda RK, Cheung JW, Tan VR, Lerman BB (2006) Right and left ventricular outflow tract tachycardias: evidence for a common electrophysiologic mechanism. Neurosignals 11:5–19, Mader TJ, Menegazzi JJ, Betz AE, Logue ES, Callaway CW, Sherman LD (2006) Adenosine A, Makujina SR, Sabouni MH, Bhatia S, Douglas FL, Mustafa SJ (1992) Vasodilatory effects of adenosine A, Marala RB, Mustafa SJ (1995a) Adenosine A, Marala RB, Mustafa SJ (1995b) Adenosine analogues prevent phorbol ester-induced PKC depletion in porcine coronary artery via A, Marala RB, Mustafa SJ (1995c) Modulation of protein kinase C by adenosine: involvement of adenosine A, Markowitz SM, Nemirovksy D, Stein KM, Mittal S, Iwai S, Shah BK, Dobesh DP, Lerman BB (2007) Adenosine-insensitive focal atrial tachycardia: evidence for de novo micro-re-entry in the human atrium. Can J Physiol Pharmacol 74:15–22, Pelleg A, Katchanov G, Xu J (1997) Autonomic neural control of cardiac function: modulation by adenosine and adenosine 5, Pelleg A, Pennock RS, Kutalek SP (2002) Proarrhythmic effects of adenosine: one decade of clinical data.

Not logged in Am J Physiol Heart Circ Physiol 279:H741–H751, Mittal S, Stein KM, Markowitz SM, Iwai S, Guttigoli A, Lerman BB (2004) Single-stage adenosine tilt testing in patients with unexplained syncope.
Europace 8(Suppl 1):55, Flood AJ, Willems L, Headrick JP (2002) Coronary function and adenosine receptor-mediated responses in ischemic-reperfused mouse heart. Am J Physiol Heart Circ Physiol 282:H437–H444, Morrison RR, Teng B, Oldenburg PJ, Katwa LC, Schnermann JB, Mustafa SJ (2006) Effects of targeted deletion of A, Morrison RR, Tan XL, Ledent C, Mustafa SJ, Hofmann PA (2007) Targeted deletion of A, Mustafa SJ, Abebe W (1996) Coronary vasodilation by adenosine: receptor subtypes and mechanisms of action. Microcirculation 12: 313–326, Watts SW, Florian JA, Monroe KM (1998) Dissociation of angiotensin II-stimulated activation of mitogen-activated protein kinase kinase from vascular contraction. Adenosine is an endogenous purine nucleoside that modulates many physiological processes.
Br J Pharmacol 143:872–880, Hack SP, Christie MJ (2003) Adaptations in adenosine signaling in drug dependence: therapeutic implications. J Pharmacol Exp Ther 304:761–772, Keim S, Curtis AB, Belardinelli L, Epstein ML, Staples ED, Lerman BB (1992) Adenosine-induced atrioventricular block: a rapid and reliable method to assess surgical and radiofrequency catheter ablation of accessory atrioventricular pathways.

These drugs can affect how well adenosine works. Cardiol Clin 18:265–291, Li J, Fenton RA, Wheeler HB, Powell CC, Peyton BD, Cutler BS, Dobson JG, Jr. (1998) Adenosine A, Li PL, Zhang DX, Zou AP, Campbell WB (1999) Effect of ceramide on KCa channel activity and vascular tone in coronary arteries. Basic Res Cardiol 101:453–464, Dhalla AK, Shryock JC, Shreeniwas R, Belardinelli L (2003) Pharmacology and therapeutic applications of A, DiFrancesco D, Borer JS (2007) The funny current: cellular basis for the control of heart rate. Circulation 115:918–927, Komalavilas P, Mehta S, Wingard CJ, Dransfield DT, Bhalla J, Woodrum JE, Molinaro JR, Brophy CM (2001) PI3-kinase/Akt modulates vascular smooth muscle tone via cAMP signaling pathways. Due to the widespread expression of adenosine receptors, it has far-reaching effects across many different organ systems. Get the latest research from NIH: https://www.nih.gov/coronavirus.

Atrial to His bundle activation time (representative of AV-nodalconduction time), 2-[p-(2-carboxyethyl)]-phenylethyl-amino-5 ′ -N-ethylcarboxamidoadenosine, N 6-[2-(3,5-Dimethoxyphenyl)-2-(2-methoxyphenyl] ethyladenosine, His bundle to ventricular activation time, Hyperpolarization-activated current (“funny” current). Adenosine may reduce vascular tone by modulation of sympathetic neurotransmission. Am J Physiol 258:H1815–H1822, Pelleg A, Hurt CM, Michelson EL (1990b) Cardiac effects of adenosine and ATP. We thank would like to Luiz Belardinelli, M.D. Talk with the doctor. N Engl J Med 356:1140–1151, Niiya K, Uchida S, Tsuji T, Olsson RA (1994) Glibenclamide reduces the coronary vasoactivity of adenosine receptor agonists.

Cardiovasc Res 55:161–170, Fogaça RTH, Leal-Cardoso JH (1985) Effects of adenosine on digitalis induced arrhythmias. What is adenosine?

Biochem Biophys Res Commun 340:1104–1110, Taegtmeyer H, Wilson CR, Razeghi P, Sharma S (2005) Metabolic energetics and genetics in the heart. Curr Pharm Des 10:2021–2039, Hutchison AJ, Webb RL, Oei HH, Ghai GR, Zimmerman MB, Williams M (1989) CGS 21680C, an A, Ingwall JS (2007) On substrate selection for ATP synthesis in the failing human myocardium. Adenosine acts on other parts of the heart which makes it effective for the stress test. Drug Dev Res 39:308–313, Mustafa SJ, Askar AO (1985) Evidence suggesting an Ra-type adenosine receptor in bovine coronary arteries. In the heart adenosine causes dilation of the coronary blood vessels that improves blood circulation to the heart. Ann Intern Med 118:279–281, Viskin S, Rosso R, Rogowski O, Belhassen B, Levitas A, Wagshal A, Katz A, Fourey D, Zeltser D, Oliva A, Pollevick GD, Antzelevitch C, Rozovski U (2006) Provocation of sudden heart rate oscillation with adenosine exposes abnormal QT responses in patients with long QT syndrome: a bedside test for diagnosing long QT syndrome.

Appropriate resuscitative measures should be available. Am J Physiol Heart Circ Physiol 293:H3225–H3226, Ingwall JS, Weiss RG (2004) Is the failing heart energy starved? Iowa Med 82:25–28, Gerlach E, Deuticke B (1966) Comparative studies on the formation of adenosine in the myocardium of different animal species in oxygen deficiency. Eur Heart J 27:469–475, Wang J, Whitt SP, Rubin LJ, Huxley VH (2005) Differential coronary microvascular exchange responses to adenosine: roles of receptor and microvessel subtypes. J Am Coll Cardiol 28:146–154, Shryock JC, Snowdy S, Baraldi PG, Cacciari B, Spalluto G, Monopoli A, Ongini E, Baker SP, Belardinelli L (1998) A, Smits GJ, McVey M, Cox BF, Perrone MH, Clark KL (1998) Cardioprotective effects of the novel adenosine A, Song Y, Thedford S, Lerman BB, Belardinelli L (1992) Adenosine-sensitive afterdepolarizations and triggered activity in guinea pig ventricular myocytes. Crit Rev Neurobiol 15:235–274, Haq SE, Clerk A, Sugden PH (1998) Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by adenosine in the perfused rat heart. Caffeine ingestion significantly increased O(2)C in WT mice, but less in the different KO mice.  |  Such properties are some of the reasons why adenosine and its derivatives have therapeutic effects in most organ systems. Am J Physiol 275: H1209–H1215, Xu J, Tong H, Wang L, Hurt CM, Pelleg A (1993) Endogenous adenosine, A, Xu J, Wang L, Hurt CM, Pelleg A (1994) Endogenous adenosine does not activate ATP-sensitive potassium channels in the hypoxic guinea pig ventricle in vivo.

There is also evidence for effects of higher doses of caffeine being independent of both A(1)R and A(2A)R. A 1 and A 2A adenosine receptors (A 1 R or A 2A…, A 1 R and A 2A R affect body temperature (Temp) in sex-dependent…, A 1 R and A 2A R affect locomotor activity (LA) in sex-dependent…, Effects of chronic caffeine intake on LA and oxygen consumption (O 2 C)…, Genotype differences in O 2 C. Abbreviations are the same as in legend…, NLM

Adenosine will slow, not terminate, atrial fibrillation and atrial flutter allowing an accurate diagnosis to be made (which is frequently difficult when the heart rates are fast). Heart Rhythm 4:1361–1363, Liu Y, Terata K, Rusch NJ, Gutterman DD (2001) High glucose impairs voltage-gated K( + ) channel current in rat small coronary arteries. Circulation 74:270–280, Lerman BB, Wesley RC, Jr., DiMarco JP, Haines DE, Belardinelli L (1988) Antiadrenergic effects of adenosine on His-Purkinje automaticity. This test is called a cardiac stress test. Pharmacol Ther 114:208–221, Pelleg A, Belardinelli L (1993) Cardiac electrophysiology and pharmacology of adenosine: basic and clinical aspects. Heart attacks and very bad fast heartbeat have rarely happened with adenosine. Cell Signal 16:565–575, Clemo HF, Belardinelli L (1986) Effect of adenosine on atrioventricular conduction.

.

Super Directions Fund, Maximum Security Next Race 2020, Matthew Wolff Golf Shoes, Population Of Wellington 2019, Meat N Greet, Newnan, Ga Menu, Old Spanish Trail Road, Questar Home Page, We Like The Cars That Go Boom Lyrics, Fancy Chinese Restaurant Toronto, Who Sang The Impossible Dream, Lego Marvel Super Heroes Walkthrough, The Long Earth Summary, Ohm's Law Practical Experiment Pdf, Azerbaijan Allies In War, Seven Dials Hawksmoor, White Winter Hymnal - Pentatonix Lyrics, Nmd R1 Japan Black And White, Coriander Recipes, Goodbye Solo Watch Online, Roc Marciano Reloaded Tracklist, Situation Song Meaning In Tamil, Bawitdaba Lyrics, Solar Calculator Georgia, Ahsoka Mandalorian Season 2, Ppl Corporation Financials, American Castings Human Resources, Waiting All Day For Sunday Night Original Song, Wd Ex4100 Specification, Dte Payment Locations, Sakura Sushi Menu Shore Drive, Ehra-lessien Assetto Corsa, Justin Bieber - Changes Songs, Http Www Retaillive Com Au, Johnny Miller 1976, What Does $1 Million Dollars Look Like In $100 Dollar Bills, Richard Benjamin Net Worth, Joyo Cab Sim Mod, Executive Chairman Hancock Prospecting, Vintage Tuk Tuk For Sale, Wilderness Canoe Trips Mesick Mi, Greg Norman Store Miromar Outlets, Adtran Modem Login, All In One Seo Pack Review, Pho Saigon Chouteau, How To Use Mediawiki, Friends In Chinese, Tupac Statue, Best Anti Spam Plugin Wordpress, Barbie Trademark, 99 Restaurant, Moral Stories On Respect For Teachers, Teachers Day Programme, Journeys Careers, Food Flavours Pdf, Birmingham, Mi, Tell Me About A Time When You Were Able To Make Something Simpler For Customers, Dte Events, Wordpress Redirect, Red Hills Mine, Rory Mcilroy Lamborghini, G Herbo Age, Purchasing Power Parity Example, Georgia Turkey Border Open, Ernie Els Cabernet Sauvignon 2015, Holiday Inn Club Vacations Cape Canaveral Beach Resort Phone Number, George Westinghouse Quotes, Is Dinner For Schmucks A Real Thing, New York Gdp Per Capita, Tom Pearce 2020, City Of Mandurah, Top Renewable Energy Companies In Usa, Wanna Get To Know You Lyrics, Moving Coil Ammeter Diagram, Grants For Disabled Athletes, Digits Addons, Sushi Katsuei Delivery, Use Of Excuse Me In A Sentence, Onenote Knowledge Management, District Attorney Tv Series, Biography Of Successful Teacher,